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Current Genomics

Editor-in-Chief

ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Mitochondria and Familial Predisposition to Breast Cancer

Author(s): Stefania Weigl, Angelo Paradiso and ">Stefania Tommasi

Volume 14, Issue 3, 2013

Page: [195 - 203] Pages: 9

DOI: 10.2174/1389202911314030005

Price: $65

Abstract

Mitochondrial genome and functional alterations are related to various diseases including cancer. In all cases, the role of these organelles is associated with defects in oxidative energy metabolism and control of tumor-induced oxidative stress. The present study examines the involvement of mitochondrial DNA in cancer and in particular in breast cancer. Furthermore, since mitochondrial DNA is maternally inherited, hereditary breast cancer has been focused on.

Keywords: Mitochondrial DNA, Hereditary breast cancer, DNA variations, Polymorphism, Mitochondrial haplogroup.


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