Abstract
Attachment to host cell surfaces is a crucial step in bacterial infections. This step is mediated by important virulence factors termed adhesins which are protein in nature. Non-covalent interactions play an important role in the structural stability of protein molecules. In the present study, the roles played by cation-π interactions in the adhesion proteins of Gram negative bacilli, Gram negative cocci and Gram positive cocci are systematically analyzed. There are significant differences in the pattern of interactions and environmental preferences like secondary structure, solvent accessibility, and stabilization centers for the amino acid residues which are involved in interactions. Among the cationic residues the role of Arg is significant in Gram negative group, while in the case of Gram positive cocci the contribution from Lys is found to be important. These results might be useful for understanding the stability patterns of adhesins in different groups of pathogenic bacteria.
Keywords: Adhesins, cation-π interactions, secondary structure, stabilization centers.
Protein & Peptide Letters
Title:Role of Cation-π Interactions in the Structural Stability of Bacterial Adhesins
Volume: 20 Issue: 6
Author(s): Anand Anbarasu
Affiliation:
Keywords: Adhesins, cation-π interactions, secondary structure, stabilization centers.
Abstract: Attachment to host cell surfaces is a crucial step in bacterial infections. This step is mediated by important virulence factors termed adhesins which are protein in nature. Non-covalent interactions play an important role in the structural stability of protein molecules. In the present study, the roles played by cation-π interactions in the adhesion proteins of Gram negative bacilli, Gram negative cocci and Gram positive cocci are systematically analyzed. There are significant differences in the pattern of interactions and environmental preferences like secondary structure, solvent accessibility, and stabilization centers for the amino acid residues which are involved in interactions. Among the cationic residues the role of Arg is significant in Gram negative group, while in the case of Gram positive cocci the contribution from Lys is found to be important. These results might be useful for understanding the stability patterns of adhesins in different groups of pathogenic bacteria.
Export Options
About this article
Cite this article as:
Anbarasu Anand, Role of Cation-π Interactions in the Structural Stability of Bacterial Adhesins, Protein & Peptide Letters 2013; 20 (6) . https://dx.doi.org/10.2174/0929866511320060008
DOI https://dx.doi.org/10.2174/0929866511320060008 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Lanthionine Synthetase Component C-Like Protein 2: A New Drug Target for Inflammatory Diseases and Diabetes
Current Drug Targets The Inflammation Network in the Pathogenesis of Erectile Dysfunction: Attractive Potential Therapeutic Targets
Current Pharmaceutical Design Structural Aspects of Peptides with Immunomodulating Activity
Mini-Reviews in Medicinal Chemistry Challenges and Perspectives of Antiplatelet Therapy in Patients with Diabetes Mellitus and Coronary Artery Disease
Current Pharmaceutical Design Intraventricular Implant of Encapsulated CNTF-Secreting Fibroblasts Ameliorates Motor Deficits in Aged Rats
Current Aging Science The Importance of TLR3 Expression and Hormonal Regulation of TLR3- Induced Immune Responses in the Human Endometrium
Current Immunology Reviews (Discontinued) Review on Documented Medicinal Plants used for the Treatment of Cancer
Current Traditional Medicine Oral and Intravenous Ibandronate in the Management of Postmenopausal Osteoporosis: A Comprehensive Review
Current Pharmaceutical Design A Review on Screening Models for Potential Therapeutic Candidates and Targets Against SARS-CoV-2
Current Drug Targets OMICS-Derived Targets for Inflammatory Gut Disorders: Opportunities for the Development of Nutrition Related Biomarkers
Endocrine, Metabolic & Immune Disorders - Drug Targets Regulation of the Unfolded Protein Response in Disease: Cellular Stress and microRNAs
Current Immunology Reviews (Discontinued) Does the MK2-dependent Production of TNFα Regulate mGluR-dependent Synaptic Plasticity?
Current Neuropharmacology Editorial (Thematic Issue: Strategies to Defeat HIV)
Current HIV Research Acute Myocarditis in Children: An Overview of Treatment and Recent Patents
Recent Patents on Inflammation & Allergy Drug Discovery GPER/GPR30 and Regulation of Vascular Tone and Blood Pressure
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Graft Versus Host Disease
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Meet Our Associate Editorial Board Member
Mini-Reviews in Medicinal Chemistry Nucleic Acid Carrier Systems Based on Polyethylenimine Conjugates for the Treatment of Metastatic Tumors
Current Medicinal Chemistry Editorial (Thematic Issue: Targeting Cell Death and Proliferation Receptors in Cancer)
Current Pharmaceutical Design The Role of IL-15 Signaling in the Induction of Innate Antiviral Responses
Current Signal Transduction Therapy