Abstract
DHA–lysophospholipids are raising considerable interest because they are recognized as being relevant to promote the biological effects of the dietary fatty acid, docosahexaenoic acid (DHA). With a view to meet the growing demand in DHA–lysophospholipids, several research works have investigated their production. DHA–lysophospholipid production can be carried out either by chemical synthesis or enzymatic synthesis using lipases or phospholipases.
While synthesizing DHA–lysophospholipids, a special attention must be paid on the stability of the products. In this frame, caution is needed to prevent DHA oxidation. The reaction conditions also need to be optimized in order to minimize the phenomenon of acyl migration which could lead to random proportions of unwanted products.
At last, analytical methods allowing identification and the quantification of different DHA–lysophospholipid isomers, have to be implemented in order to monitor the production.
Keywords: Acyl migration, docosahexaenoic acid, lipase, lysophospholipid, oxidation, phospholipase.
Current Organic Chemistry
Title:DHA–lysophospholipid Production
Volume: 17 Issue: 8
Author(s): Gaelle Pencreac’h, Francoise Ergan and Laurent Poisson
Affiliation:
Keywords: Acyl migration, docosahexaenoic acid, lipase, lysophospholipid, oxidation, phospholipase.
Abstract: DHA–lysophospholipids are raising considerable interest because they are recognized as being relevant to promote the biological effects of the dietary fatty acid, docosahexaenoic acid (DHA). With a view to meet the growing demand in DHA–lysophospholipids, several research works have investigated their production. DHA–lysophospholipid production can be carried out either by chemical synthesis or enzymatic synthesis using lipases or phospholipases.
While synthesizing DHA–lysophospholipids, a special attention must be paid on the stability of the products. In this frame, caution is needed to prevent DHA oxidation. The reaction conditions also need to be optimized in order to minimize the phenomenon of acyl migration which could lead to random proportions of unwanted products.
At last, analytical methods allowing identification and the quantification of different DHA–lysophospholipid isomers, have to be implemented in order to monitor the production.
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Cite this article as:
Pencreac’h Gaelle, Ergan Francoise and Poisson Laurent, DHA–lysophospholipid Production, Current Organic Chemistry 2013; 17 (8) . https://dx.doi.org/10.2174/1385272811317080005
DOI https://dx.doi.org/10.2174/1385272811317080005 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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