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Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Iron (III) Trichloride-Catalyzed One-Pot Three-Component Coupling of Indoles and Sodium Nitrite: A Convenient Synthesis of 2,3’-Bi(3H-indol)-3-one oximes

Author(s): Hongen Qu, Wenbing Qin, Qiong Chang, Qiaosheng Hu and Liangxian Liu

Volume 17, Issue 7, 2013

Page: [756 - 762] Pages: 7

DOI: 10.2174/1385272811317070009

Price: $65


A simple, convenient and efficient three-component coupling (TCC) reaction toward a variety of (E)-2,3'-bi(3H-indol)-3-one oxime derivatives has been developed. This transformation proceeds via an iron (III)-catalyzed tandem coupling reaction between indoles and sodium nitrite. This methodology provides an alternative approach for easy access of (E)-2,3'-bi(3H-indol)-3-one oximes in good to excellent yields at room temperature.

Keywords: Indoles, iron (III) trichloride, biindoles, tandem reactions, three-component coupling reaction.

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