Abstract
Transient receptor potential (TRP) cation channels are an emerging field of research in dermatology. Beyond their classical role in skin sensory perception, TRPs are involved in various cutaneous functions that include keratinocyte differentiation, apoptosis and melanocyte pigmentation. In addition, they have a role as pharmacological targets in many inflammatory skin diseases including psoriasis, chronic itch, hair disorders and skin cancers. Moreover, mutations in TRPs have recently been related to rare skin conditions such as Olmsted syndrome. This review will cover the role of TRPs in dermatologic conditions with special emphasis on itch and skin inflammatory diseases.
Keywords: TRPV, TRPA, TRPM, TRPC, TRPML, Itch, skin barrier, hair growth, skin cancers
Current Topics in Medicinal Chemistry
Title:Transient Receptor Potential Channels and Dermatological Disorders
Volume: 13 Issue: 3
Author(s): Rodrigo Valdes-Rodriguez, Shivani B. Kaushik and Gil Yosipovitch
Affiliation:
Keywords: TRPV, TRPA, TRPM, TRPC, TRPML, Itch, skin barrier, hair growth, skin cancers
Abstract: Transient receptor potential (TRP) cation channels are an emerging field of research in dermatology. Beyond their classical role in skin sensory perception, TRPs are involved in various cutaneous functions that include keratinocyte differentiation, apoptosis and melanocyte pigmentation. In addition, they have a role as pharmacological targets in many inflammatory skin diseases including psoriasis, chronic itch, hair disorders and skin cancers. Moreover, mutations in TRPs have recently been related to rare skin conditions such as Olmsted syndrome. This review will cover the role of TRPs in dermatologic conditions with special emphasis on itch and skin inflammatory diseases.
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Cite this article as:
Valdes-Rodriguez Rodrigo, B. Kaushik Shivani and Yosipovitch Gil, Transient Receptor Potential Channels and Dermatological Disorders, Current Topics in Medicinal Chemistry 2013; 13 (3) . https://dx.doi.org/10.2174/15680266112129990090
DOI https://dx.doi.org/10.2174/15680266112129990090 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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