Transient Receptor Potential Channels and Dermatological Disorders

Rodrigo      Valdes-Rodriguez; Shivani      B. Kaushik; Gil      Yosipovitch

Abstract

Transient receptor potential (TRP) cation channels are an emerging field of research in dermatology. Beyond their classical role in skin sensory perception, TRPs are involved in various cutaneous functions that include keratinocyte differentiation, apoptosis and melanocyte pigmentation. In addition, they have a role as pharmacological targets in many inflammatory skin diseases including psoriasis, chronic itch, hair disorders and skin cancers. Moreover, mutations in TRPs have recently been related to rare skin conditions such as Olmsted syndrome. This review will cover the role of TRPs in dermatologic conditions with special emphasis on itch and skin inflammatory diseases.

Keywords: TRPV, TRPA, TRPM, TRPC, TRPML, Itch, skin barrier, hair growth, skin cancers