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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Copper-Catalyzed Synthesis of Isoquinolines by the Cyclocondensation of ortho- Alkynyl Aromatic Aldehydes or Ketones with Urea

Author(s): Jia Ju and Ruimao Hua

Volume 10, Issue 2, 2013

Page: [328 - 332] Pages: 5

DOI: 10.2174/1570179411310020007

Price: $65


A simple and efficient synthesis of isoquinoline derivatives by the condensation of ortho-alkynyl aromatic aldehydes/ketones with urea in the presence of copper salts is developed.

Keywords: o-Alkynyl aromatic aldehyde, o-Alkynyl aromatic ketone, cyclocondensation, isoquinoline derivative, urea

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