Abstract
Guanine-rich sequences found at telomeres and oncogenes have the capacity to form G-quadruplex (G4) structures. It has been found a relationship between the ability to stabilizing G4 structures and anticancer activity. Guanine quadruplexes stabilization and its implication in cancer phenomena is a therapeutic target relatively recent. Computeraided drug design has been a very useful tool for the search of new candidates. In last years, methodologies have improved with the development of the computational sciences. The hardware is also enhanced, new techniques are explored. NMR and X-ray information about different targets are discovered continually. The continuous augmentation of new powerful and comprehensive software’s with this purpose is other significant factor that contributes to the discovering of new compounds. Nevertheless computer-aided drug design has not been vastly employed in the design of new compound with G4 stabilization activity. All things considered, this review will be focused on the influence of computational techniques on speeding up the discovery of new G4 ligands.
Keywords: Cancer, drug design, G-quadruplex, oncogenes
Current Topics in Medicinal Chemistry
Title:Computational Tools in the Discovery of New G-Quadruplex Ligands with Potential Anticancer Activity
Volume: 12 Issue: 24
Author(s): Daimel Castillo-Gonzalez, Gisselle Perez-Machado, Federico Pallardo, Teresa-Maria Garrigues-Pelufo and Miguel-Angel Cabrera-Perez
Affiliation:
Keywords: Cancer, drug design, G-quadruplex, oncogenes
Abstract: Guanine-rich sequences found at telomeres and oncogenes have the capacity to form G-quadruplex (G4) structures. It has been found a relationship between the ability to stabilizing G4 structures and anticancer activity. Guanine quadruplexes stabilization and its implication in cancer phenomena is a therapeutic target relatively recent. Computeraided drug design has been a very useful tool for the search of new candidates. In last years, methodologies have improved with the development of the computational sciences. The hardware is also enhanced, new techniques are explored. NMR and X-ray information about different targets are discovered continually. The continuous augmentation of new powerful and comprehensive software’s with this purpose is other significant factor that contributes to the discovering of new compounds. Nevertheless computer-aided drug design has not been vastly employed in the design of new compound with G4 stabilization activity. All things considered, this review will be focused on the influence of computational techniques on speeding up the discovery of new G4 ligands.
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Castillo-Gonzalez Daimel, Perez-Machado Gisselle, Pallardo Federico, Garrigues-Pelufo Teresa-Maria and Cabrera-Perez Miguel-Angel, Computational Tools in the Discovery of New G-Quadruplex Ligands with Potential Anticancer Activity, Current Topics in Medicinal Chemistry 2012; 12 (24) . https://dx.doi.org/10.2174/1568026611212240010
DOI https://dx.doi.org/10.2174/1568026611212240010 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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