Abstract
Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.
Keywords: 5-lipoxygenase, FLAP, LTA4-hydrolase, leukotrienes, antileukotrienic agents
Current Medicinal Chemistry
Title: 5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents
Volume: 13 Issue: 2
Author(s): Josef Jampilek, Martin Dolezal, Veronika Opletalova and Jiri Hartl
Affiliation:
Keywords: 5-lipoxygenase, FLAP, LTA4-hydrolase, leukotrienes, antileukotrienic agents
Abstract: Leukotrienes play an important role in the inflammatory process accompanying allergic diseases of respiratory, gastrointestinal and dermatological systems. Leukotrienes are generated from arachidonic acid as a result of the 5-lipoxygenase action. This paper deals with 5-lipoxygenase action mechanism and the following biosynthesis of all leukotrienes. In this article, potential antileukotrienic agents are classified according to their mechanism of action. The original antileukotrienic compounds of the Research Institute for Pharmacy and Biochemistry in Prague (VUFB), Czech Republic are presented in a separate chapter of the paper.
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Cite this article as:
Jampilek Josef, Dolezal Martin, Opletalova Veronika and Hartl Jiri, 5-Lipoxygenase, Leukotrienes Biosynthesis and Potential Antileukotrienic Agents, Current Medicinal Chemistry 2006; 13 (2) . https://dx.doi.org/10.2174/092986706775197935
DOI https://dx.doi.org/10.2174/092986706775197935 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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