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Anti-Cancer Agents in Medicinal Chemistry


ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Understanding Apoptosis in Terms of QSAR

Author(s): Rajeshwar P. Verma

Volume 6, Issue 1, 2006

Page: [41 - 52] Pages: 12

DOI: 10.2174/187152006774755528


Apoptosis is a cellular mechanism by which unwanted, defective, or damaged cells are rapidly and selectively eliminated to maintain healthy tissue homeostasis in multi-cellular organisms. In this review, we have developed nineteen quantitative structure-activity relationships (QSAR) for different series of compounds with respect to their apoptotic activities against five different cancer cell lines that are T47D, ZR75-1, DLD-1, H1299, and HL60 in order to understand chemical-biological interactions.

Keywords: Apoptosis, hydrophobicity, molar refractivity, molar volume, quantitative structure-activity relationship (QSAR)

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