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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Quinolines as Chemotherapeutic Agents for Leishmaniasis

Author(s): Kristie A. Reynolds, Wendy A. Loughlin and David J. Young

Volume 13, Issue 5, 2013

Page: [730 - 743] Pages: 14

DOI: 10.2174/1389557511313050010

Price: $65


The development of leishmanicidal quinolines and their in vitro (promastigote and amastigote) and, where applicable, in vivo activities are reviewed. This survey provides a direct comparison of bioactivity across different species (e.g. L. donovani, L. amazonensis, L. chagasi, L infantum), and in different animal models (e.g. L. donovani Balb/c mice and L. donovani infected hamsters). The progress of selected quinolines through pre-clinical development and phase I/II trials, and the lead quinoline drugs sitamaquinine and Imiquimod, are discussed in conjunction with delivery systems and combination therapies.

Keywords: Leishmaniasis, quinolines, affordable chemotherapies

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