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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Certain 2-Furano-4(3H)-Quinazolinone Analogs: Synthesis, Characterization and Pharmacological Evaluation

Author(s): Varun Bhardwaj, Poonam Sharma, Malleshappa N. Noolvi, Harun M. Patel, Sumit Bansal, Sandeep Lohan and Gaurav Badola

Volume 10, Issue 4, 2013

Page: [360 - 368] Pages: 9

DOI: 10.2174/1570180811310040010

Price: $65


A series of new of 2-furano-4(3H)-quinazolinone derivatives 5 (a-t) were synthesized. The compounds were characterized by their IR, 1H NMR, 13C NMR, and Mass spectral data. The antimicrobial activity of newly anthranilic acid-based compounds against various bacteria; S. aureus, Salmonella enterica, Vibrio cholerae, Bacillus subtilis, Proteus mirabili, Escherichia coli V517, Mycobacterium smegmatics, Pseudomonas aeruginosa and fungi; C. albicans, were evaluated with ampicillin and amphotericin B as standards. All compounds were also evaluated for antibacterial activity against R. solanacearum along with Kocide 3000 as a commercialized reference. Compounds 5d, 5g, 5j, 5l, 5q, 5r, 5s, and 5t exhibited good potential as antimicrobial.

Keywords: Synthesis, Quinazolinone, Diamide (open quinazoline ring), Antimicrobial activity

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