Abstract
The resistance of infectious bacteria to current antibiotics is a worldwide problem. Previous studies have demonstrated the efficacy of nanostructured molecules against pathogens as an innovative methodology for the development of novel drugs. Currently, 95% of properties limited pharmacies applicability such as low solubility, short half-life in the circulatory system, toxicity associated to controlled release and immunogenicity. Furthermore, nanobiotechnology provides a different perspective for modifying these properties and allows innovative drug development. In this context, this review aims to describe different methods, polymers, and drugs used to obtain and analyze nanostructures associated with antibiotics as an unconventional and innovative tool for bacterial control. Biotechnology provides a different perspective for modifying drug properties and allows innovative drug development. This review describes nanostructures in association with antibiotics as an unconventional and innovative tool for bacterial control.
Keywords: Antibiotics, bacteria, nanoparticles, antimicrobial peptides, infectious diseases
Current Medicinal Chemistry
Title:Nanoformulated Antibiotics: the Next Step for Pathogenic Bacteria Control
Volume: 20 Issue: 10
Author(s): Amanda Caroline Marques Saude, Mariana Dornelles Cherobim, Andre Correa Amaral, Simoni Campos Dias and Octavio Luiz Franco
Affiliation:
Keywords: Antibiotics, bacteria, nanoparticles, antimicrobial peptides, infectious diseases
Abstract: The resistance of infectious bacteria to current antibiotics is a worldwide problem. Previous studies have demonstrated the efficacy of nanostructured molecules against pathogens as an innovative methodology for the development of novel drugs. Currently, 95% of properties limited pharmacies applicability such as low solubility, short half-life in the circulatory system, toxicity associated to controlled release and immunogenicity. Furthermore, nanobiotechnology provides a different perspective for modifying these properties and allows innovative drug development. In this context, this review aims to describe different methods, polymers, and drugs used to obtain and analyze nanostructures associated with antibiotics as an unconventional and innovative tool for bacterial control. Biotechnology provides a different perspective for modifying drug properties and allows innovative drug development. This review describes nanostructures in association with antibiotics as an unconventional and innovative tool for bacterial control.
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Cite this article as:
Caroline Marques Saude Amanda, Dornelles Cherobim Mariana, Correa Amaral Andre, Campos Dias Simoni and Luiz Franco Octavio, Nanoformulated Antibiotics: the Next Step for Pathogenic Bacteria Control, Current Medicinal Chemistry 2013; 20 (10) . https://dx.doi.org/10.2174/0929867311320100004
DOI https://dx.doi.org/10.2174/0929867311320100004 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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