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Current Drug Discovery Technologies


ISSN (Print): 1570-1638
ISSN (Online): 1875-6220

Systems Biology Approaches in Identifying the Targets of Natural Compounds for Cancer Therapy

Author(s): Yi Tan, Qiong Wu, Jun Xia, Lucio Miele, Fazlul H Sarkar and Zhiwei Wang

Volume 10 , Issue 2 , 2013

Page: [139 - 146] Pages: 8

DOI: 10.2174/1570163811310020006

Price: $65


Natural compounds have been known to exert inhibitory effects on the development and progression of human cancers. However, the targets of these naturally occurring agents are largely elusive. Recently, systems biology approaches based on high-throughput technologies such as DNA microarrays have begun to be utilized for investigating the targets of drugs including natural compounds. Therefore, in this review article, we will briefly introduce the several systems biology approaches, and will discuss the application of these new technologies for identifying the therapeutic targets of natural compounds for supporting their roles in the prevention and/or treatment of human cancers. Furthermore, identification of the novel targets will be useful for designing more effective and targeted therapeutic strategies for achieving better treatment outcome in patients diagnosed with cancers.

Keywords: Apoptosis, cDNA microarray, cell growth, miRNA microarray, natural compounds, systems biology

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