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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Alterations of Brain Membranes in Schizophrenia: Impact of Phospholipase A2

Author(s): E.L. Schaeffer, W.F. Gattaz and G.P. Eckert

Volume 12, Issue 21, 2012

Page: [2314 - 2323] Pages: 10

DOI: 10.2174/1568026611212210004

Price: $65

Abstract

Physiological enzymatic cleavage of membrane phospholipids by phospholipase A2 (PLA2) results in normal levels of phosphomonoester and phosphodiester, by which a normal dopamine neurotransmission is maintained. Data from postmortem tissue and in vivo imaging studies suggest that increased activity of intracellular calcium-independent PLA2 (iPLA2) in the brain of schizophrenic patients might accelerate the breakdown of membrane phospholipids and alter the properties of neuronal membranes, which in turn contributes to a hypodopaminergy. Alterations in PLA2 activity are probably genetically determined and represent a possible pharmacological target for Schizophrenia.

Keywords: schizophrenia, neuroimaging, membrane, phospholipase A2, dopamine


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