Application of Targeted Therapy to Malignant Gliomas and Response to Treatment

Title:Application of Targeted Therapy to Malignant Gliomas and Response to Treatment

Volume: 8 Issue: 1

Author(s): Eudocia Q. Lee, Andrew D. Norden, Jan Drappatz and Patrick Y. Wen

Affiliation:

Keywords: Targeted therapy, malignant glioma, angiogenesis, clinical trials, multi-targeted therapy, "malignant gliomas", cellular signaling kinases

Abstract: The prognosis for malignant gliomas remains poor despite multimodality therapy. An increased understanding of the molecular pathogenesis involved in glioma development and growth has resulted in development of agents that specifically target these molecular processes and pathways. Except for inhibitors of the vascular endothelial growth factor pathway, results from most single agent trials have been modest at best. Tailoring therapy to the individual patients is an attractive strategy although most studies have failed to determine predictive biomarkers. Numerous novel agents, multitargeted agents, and combination therapies are now in clinical trials for malignant glioma.

Cite this article as:

Q. Lee Eudocia, D. Norden Andrew, Drappatz Jan and Y. Wen Patrick, Application of Targeted Therapy to Malignant Gliomas and Response to Treatment, Current Signal Transduction Therapy 2013; 8 (1) . https://dx.doi.org/10.2174/1574362411308010004