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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Marine Natural Products with Anti-HIV Activities in the Last Decade

Author(s): Xuefeng Zhou, Juan Liu, Bin Yang, Xiuping Lin, Xian-Wen Yang and Yonghong Liu

Volume 20, Issue 7, 2013

Page: [953 - 973] Pages: 21

DOI: 10.2174/0929867311320070009

Price: $65


Marine organisms have been proven to be excellent sources of biologically active compounds against HIV. This review gives an overview of 132 natural products from marine sources obtained during the last decade (2002–2011), which exhibit anti-HIV activity toward different biological targets. Sponges contribute more than half of all anti-HIV natural products from marine organisms, mainly as alkaloids and cyclic depsipeptides. In addition, some macromolecules are considered as potential anti-HIV agents, including lectins from algae and marine invertebrates, as well as sulfated polysaccharides from algae. In the reviewed marine natural products, many active ingredients act as HIV entry inhibitors, one class of new anti-HIV agents, and may be regarded as potential candidates for the development of novel anti-HIV agents. The other features of development in the marine original anti-HIV natural products in this ten years are also discussed.

Keywords: Anti-HIV, HIV entry inhibitors, last decade, marine organisms, natural products, sponges, Marine Natural Products, biologically active compounds, 132 natural products, macromolecules

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