Chloroformate Free, Scalable Approach for the Synthesis of Organic Carbamates and Their Alkylation

Title:Chloroformate Free, Scalable Approach for the Synthesis of Organic Carbamates and Their Alkylation

Volume: 10 Issue: 1

Author(s): Mukesh P. Shewalkar, Ramakrishna R. Rao, Veerbhadra Reddy, Sunil N. Darandale and Devanand B. Shinde

Affiliation:

Keywords: Alkylation, alkyl aminopyridine, 2-aminopyridine, Boc anhydride, carbamates, prodrugs, maytansine, alkylation, toxic, economical method, chemicals

Abstract: A convenient method for the synthesis of organic carbamates of 2-aminopyridine without using hazardous chloroformate reagent is developed. This alternate approach for the synthesis of organic carbamates and their alkylation to 2-alkylaminopyridines is more practical and economical to be used on large scale. The amazing behavior of 2- aminopyridine helps in forming organic carbamates unlike 3-aminopyridine and 4-aminopyridine.

Cite this article as:

P. Shewalkar Mukesh, R. Rao Ramakrishna, Reddy Veerbhadra, N. Darandale Sunil and B. Shinde Devanand, Chloroformate Free, Scalable Approach for the Synthesis of Organic Carbamates and Their Alkylation, Letters in Organic Chemistry 2013; 10 (1) . https://dx.doi.org/10.2174/1570178611310010014