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Current Analytical Chemistry


ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

Purification of Transcription Factors and Identification with Mass Spectrometry

Author(s): Shoulei Jiang, Linda Nagore, Daifeng Jiang, Robert A. Moxley and Harry W. Jarrett

Volume 3, Issue 4, 2007

Page: [272 - 282] Pages: 11

DOI: 10.2174/157341107782109626

Price: $65


Transcription factors are a large and diverse group of proteins which bind to DNA response elements in the promoters of genes either activating or repressing gene expression. The purification and characterization of transcription factors has been improving at a rapid pace. New purification techniques, including oligonucleotide trapping, and improved methods of detection, including chromatin immunoprecipitation have been combined with improved characterization using mass spectrometry methods. Here, we review and give examples of many of these recent advances.

Keywords: Reviews, Transcription factors, Purification, Mass spectrometry, Proteomics

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