Synthesis and Biological Activities of Sulfinyl Acetamide Derivatives for Narcolepsy Treatment

Title:Synthesis and Biological Activities of Sulfinyl Acetamide Derivatives for Narcolepsy Treatment

Volume: 10 Issue: 3

Author(s): Xiong Zhu, Jinpei Zhou, Yan Zhu, Xiaowen Hu, Yuemin Bian, Xinting Hu, Zhuo Tao, Cong Gao and Wenlong Huang

Affiliation:

Keywords: Narcolepsy; Modafinil; Sulfinyl acetamide; Synthesis; Central nervous system stimulant.

Abstract: In order to develop new narcolepsy treatment agents, a series of modafinil derivatives were designed and synthesized. In this paper the tricycle structure with sulfinyl acetamide moiety was adopted as alternate scaffold. Fifteen novel modafinil derivatives were developed by a parallel synthesis approach and evaluated for their central nervous system stimulant effects. Preliminary tests showed that some of the target compounds manifested strong central nervous system stimulant activity, especially 6k proved to be the most promising compound.

Cite this article as:

Zhu Xiong, Zhou Jinpei, Zhu Yan, Hu Xiaowen, Bian Yuemin, Hu Xinting, Tao Zhuo, Gao Cong and Huang Wenlong, Synthesis and Biological Activities of Sulfinyl Acetamide Derivatives for Narcolepsy Treatment, Letters in Drug Design & Discovery 2013; 10 (3) . https://dx.doi.org/10.2174/1570180811310030010