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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Biological Activities of Sulfinyl Acetamide Derivatives for Narcolepsy Treatment

Author(s): Xiong Zhu, Jinpei Zhou, Yan Zhu, Xiaowen Hu, Yuemin Bian, Xinting Hu, Zhuo Tao, Cong Gao and Wenlong Huang

Volume 10 , Issue 3 , 2013

Page: [266 - 270] Pages: 5

DOI: 10.2174/1570180811310030010

Price: $65


In order to develop new narcolepsy treatment agents, a series of modafinil derivatives were designed and synthesized. In this paper the tricycle structure with sulfinyl acetamide moiety was adopted as alternate scaffold. Fifteen novel modafinil derivatives were developed by a parallel synthesis approach and evaluated for their central nervous system stimulant effects. Preliminary tests showed that some of the target compounds manifested strong central nervous system stimulant activity, especially 6k proved to be the most promising compound.

Keywords: Narcolepsy; Modafinil; Sulfinyl acetamide; Synthesis; Central nervous system stimulant.

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