Abstract
Anti-inflammatory drugs consist of non-steroidal anti-inflammatory drugs (NSAIDs) including non-selective nsNSAIDs, aspirin, and cyclooxygenase-2 (COX-2)-selective inhibitors also referred to as coxibs, and glucocorticoids (GCs). They are worldwide prescribed drugs for many musculoskeletal conditions, such as osteoarthritis and inflammatory rheumatic diseases. Anti-inflammatory drugs can exert deleterious effects on the cardiovascular system, excluding aspirin. NSAIDs, especially coxibs, have been demonstrated to increase cardiovascular risk and have generated many concerns leading to the reassessment of their benefit/risk ratio. GCs may also induce cardiovascular events, but evidence seems to be less clear. Before prescribing these drugs, an assessment of cardiovascular risk may be judicious. In this review, anti-inflammatory drugs, coxibs, nsNSAIDs and GCs, and the risk of cardiovascular events will be discussed.
Keywords: Cardiovascular system, cardiovascular diseases, anti-inflammatory agents, NSAIDs, cyclooxygenase 2 inhibitors, glucocorticoids
Related Journals
Related Books
Molecular Aspects of Hepatocellular Carcinoma
Current Diagnosis of Infant Tuberculosis Infection
Physiopathogenesis of Hematological Cancer
The Role of New Technologies in Medical Microbiological Research and Diagnosis
The Role of Saliva Cortisol Measurement in Health and Disease
Current Topics on Fetal 3D/4D Ultrasound
Molecular Oncology: Principles and Recent Advances
Multi Drug Resistance: A Global Concern
Awake Thoracic Surgery
Preventive Female Sex Factors Against The Development of Chronic Liver Disease
74