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Anti-Cancer Agents in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1871-5206
ISSN (Online): 1875-5992

Functional Nanoplatforms for Enhancement of Chemotherapeutic Index

Author(s): Jaemoon Yang, Eugene Lee, Minhee Ku, Yong-Min Huh and Jae-Ho Cheong

Volume 13, Issue 2, 2013

Page: [212 - 221] Pages: 10

DOI: 10.2174/1871520611313020005

Price: $65

Abstract

Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.

Keywords: Anti-cancer agents, Cancer, Combination chemotherapy, Nanoparticle, Synergistic effect


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