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Medicinal Chemistry


ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Synthesis and Biological Activities of New Halophenols

Author(s): FeiLang Zheng, ShuRong Ban, XiuE Feng, ChengXiao Zhao, GuanHua Du and QingShan Li

Volume 9 , Issue 2 , 2013

Page: [303 - 311] Pages: 9

DOI: 10.2174/1573406411309020013

Price: $65


A series of new halophenols were synthesized, and their structures were established on the basis of 1H, 13C NMR and mass spectral data. All of the prepared compounds were screened for their in vitro protein tyrosine kinase (PTK) and vascular smooth muscle cell (VSMC) proliferation inhibitory activity. Twelve halophenols showed significant PTK inhibitory activity, most of them exhibited stronger activities than that of genistein, a positive reference compound. Several halophenols also displayed moderate VSMC proliferation inhibitory activity, compound 8c showed higher activity than that of tetrandrine, a positive reference compound. The preliminary structure–activity relationships of these compounds were investigated and discussed. The results provided a foundation for the action mechanism study and further structure optimization of the halophenols.

Keywords: Halophenols, furan-2-yl(phenyl)methanone, protein tyrosine kinase (PTK) inhibitor, vascular smooth muscle cell (VSMC) proliferation inhibitor, Structure–activity relationships (SAR)

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