Synthesis of Benzopyran Linked Pyrrolo[2,1-c][1,4]benzodiazepines as DNA-Binding and Potential Anticancer Agents

Ahmed      Kamal; Rajender; Methuku      Kashi Reddy; Vangala      Santhosh Reddy; Gajjela      Bharath Kumar

Abstract

A series of twelve benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized. They exhibit significant DNA-binding activity and excellent cytotoxic activity against various human cancer cell lines.

Keywords: Cytotoxicity, DNA-Binding affinity, 2, 2-Dimethyl benzopyran, Pyrrolo[2, 1-c][1, 4]benzodiazepines and Piperazine

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Medicinal Chemistry

Title:Synthesis of Benzopyran Linked Pyrrolo[2,1-c][1,4]benzodiazepines as DNA-Binding and Potential Anticancer Agents

Volume: 9 Issue: 2

Author(s): Ahmed Kamal, Rajender, Methuku Kashi Reddy, Vangala Santhosh Reddy and Gajjela Bharath Kumar

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Keywords: Cytotoxicity, DNA-Binding affinity, 2, 2-Dimethyl benzopyran, Pyrrolo[2, 1-c][1, 4]benzodiazepines and Piperazine

Abstract: A series of twelve benzopyran linked pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized. They exhibit significant DNA-binding activity and excellent cytotoxic activity against various human cancer cell lines.

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Kamal Ahmed, Rajender , Kashi Reddy Methuku, Santhosh Reddy Vangala and Bharath Kumar Gajjela, Synthesis of Benzopyran Linked Pyrrolo[2,1-c][1,4]benzodiazepines as DNA-Binding and Potential Anticancer Agents, Medicinal Chemistry 2013; 9 (2) . https://dx.doi.org/10.2174/1573406411309020003

DOI https://dx.doi.org/10.2174/1573406411309020003	Print ISSN 1573-4064
Publisher Name Bentham Science Publisher	Online ISSN 1875-6638

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