Abstract
A concise chemical synthesis of the common tetrasaccharide corresponding to the O-antigen of enteroinvasive Escherichia coli O143 and Shigella boydii type 8 has been achieved in excellent yield. Application of [2+2] block glycosylation and late stage oxidation of primary hydroxyl groups to the carboxylic groups are notable features in the synthetic strategy.
Keywords: Escherichia coli, Shigella boydii, O-antigen, tetrasaccharide, dysentery
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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