Novel 2-pyrazolin-1-ylthiazoles as Potential Antimicrobial Agents

Title:Novel 2-pyrazolin-1-ylthiazoles as Potential Antimicrobial Agents

Volume: 10 Issue: 2

Author(s): Bakr Fathy Abdel-Wahab, Ashraf Sediek, Hanan Ahmed Mohamed and Ghada Elsayed Ahmed Awad

Affiliation:

Keywords: Pyrazole, Antimicrobial activity, Hydrazonoyl chlorides, Pyrazoline-1-thioamide, 2-Pyrazoline-1-ylthiazoles, X-ray, JASCO FT/IR-6100, dimethylformamide, Pseudomonas, Candida Albicans

Abstract: A series of 2-(5-(4-fluorophenyl)-pyrazolin-1-yl)thiazoles prepared as potential antimicrobial agents is described. The synthesis involved the reaction of 5-(4-fluorophenyl)-3-heterocycl-4,5-dihydro-1H-pyrazole-1- carbothioamides 4a,b with various hydrazonoyl chlorides 5 or phenacyl bromides 8-10. These compounds were structurally characterized. The structure of 7 was confirmed by studying the X-ray crystallographic. The antimicrobial evaluations of the newly synthesized products against broad spectrum of bacteria and fungi were performed.

Cite this article as:

Fathy Abdel-Wahab Bakr, Sediek Ashraf, Ahmed Mohamed Hanan and Elsayed Ahmed Awad Ghada, Novel 2-pyrazolin-1-ylthiazoles as Potential Antimicrobial Agents, Letters in Drug Design & Discovery 2013; 10 (2) . https://dx.doi.org/10.2174/157018013804725143