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Current Rheumatology Reviews


ISSN (Print): 1573-3971
ISSN (Online): 1875-6360

Heart Valve Lesions In The Antiphospholipid Syndrome

Author(s): Ricard Cervera and Gerard Espinosa

Volume 8, Issue 3, 2012

Page: [161 - 165] Pages: 5

DOI: 10.2174/157339710803140210193810

Price: $65


The antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies (aPL), hypercoagulability leading to vascular thrombosis, and pregnancy morbidity. Since its recognition, a great number of cardiac manifestations have been reported in association with these antibodies, but heart valve abnormalities are the most common cardiac manifestations of the syndrome. They include valve thickness >3 mm, localized thickening involving the leaflet’s proximal or middle portion, and/or irregular nodules on the atrial face of the edge of the mitral valve, and/or the vascular face of the aortic valve. A consensus committee recommended anticoagulation in symptomatic valvular disease. Asymptomatic patients should be prophylactically treated with aspirin.

Keywords: Antiphospholipid antibodies, anticardiolipin antibodies, lupus anticoagulant, systemic lupus erythematosus.

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