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Current Pharmaceutical Biotechnology


ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Current Status and Future Prospects for Research on Tyrosine Sulfation

Author(s): Nobuya Sasaki

Volume 13, Issue 14, 2012

Page: [2632 - 2641] Pages: 10

DOI: 10.2174/138920101314151120122922

Price: $65


Tyrosine (Tyr) sulfation is a common posttranslational modification of secreted proteins or membrane-bound proteins that is implicated in numerous physiological and pathological processes. The Tyr sulfation modifies proteinprotein interactions involved in leukocyte adhesion, homeostasis, and receptor-mediated signaling. To data, 80 Tyrsulfated proteins have been identified. As new methodologies and bioinformatics for the detection of Tyr sulfation become available, the number of Tyr-sulfated acceptor proteins discovered is bound to increase. Further, recent advances in microscopy and fluorescence technology will provide information on the true spatial and temporal nature of Tyr-sulfated proteins within the intact cell. This review summarizes the methods for the detection of Tyr O-sulfation as well as the biological functions of sulfated Tyr. Further, illustrative examples of the impact of Tyr sulfation on the pharmacological properties are presented.

Keywords: Tyrosine sulfation, tyrosine O-sulfation, tyrosylprotein sulfotransferase, TPST, posttranslational modification, membrane-bound proteins, numerous physiological, pathological processes, leukocyte adhesion, bioinformatics, homeostasis, fluorescence technology, intact cell, true spatial

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