Abstract
Hypertension is one of the major causes of cardiovascular morbidity. Most patients who are on treatment for hypertension fail to achieve adequate control with the existing therapy and rates of cardiovascular morbidity remain high. As the renin-angiotensin-aldosterone system is strongly implicated in the development of hypertension-related target organ damage, intensive efforts have been devoted towards the development of drugs targeting this system. In addition to angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), inhibition of renin has also become a clinical reality. Aliskiren, a novel renin inhibitor, has overcome a number of shortcomings of existing drugs and is now available to address angiotensin production directly at its rate-limiting step.
Keywords: Renin inhibitor, SPP100, aliskiren, hypertension
Current Drug Therapy
Title: Aliskiren: A Novel Renin Inhibitor for Hypertension
Volume: 2 Issue: 3
Author(s): Vandana Tayal and Bhupinder Singh Kalra
Affiliation:
Keywords: Renin inhibitor, SPP100, aliskiren, hypertension
Abstract: Hypertension is one of the major causes of cardiovascular morbidity. Most patients who are on treatment for hypertension fail to achieve adequate control with the existing therapy and rates of cardiovascular morbidity remain high. As the renin-angiotensin-aldosterone system is strongly implicated in the development of hypertension-related target organ damage, intensive efforts have been devoted towards the development of drugs targeting this system. In addition to angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs), inhibition of renin has also become a clinical reality. Aliskiren, a novel renin inhibitor, has overcome a number of shortcomings of existing drugs and is now available to address angiotensin production directly at its rate-limiting step.
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Cite this article as:
Tayal Vandana and Kalra Singh Bhupinder, Aliskiren: A Novel Renin Inhibitor for Hypertension, Current Drug Therapy 2007; 2 (3) . https://dx.doi.org/10.2174/157488507781695667
DOI https://dx.doi.org/10.2174/157488507781695667 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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