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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Histamine H3 Receptor Function and Ligands: Recent Developments

Author(s): Mahaveer Singh and Hemant R. Jadhav

Volume 13, Issue 1, 2013

Page: [47 - 57] Pages: 11

DOI: 10.2174/1389557511307010047

Price: $65


Histamine H3 receptors are found mostly in central nervous system involved in the regulation of release of various neurotransmitters in brain. They have been implicated in diverse potential therapeutic applications such as sleepwake disorders, attention-deficient hyperactivity disorder, epilepsy, cognitive impairment and obesity. This review is an attempt to elucidate the function of H3 receptors and their role in various CNS disorders. Also, it is aimed at collating the information on efforts of various medicinal chemists to synthesize the H3 receptor agonists and antagonists in single article.

Keywords: Epilepsy, H3 Receptors, Obesity, H3 Receptor Antagonists

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