Abstract
After myocardial infarction, the lost healthy myocardium is replaced by non-contractile scar tissue which may lead to the development of heart failure and death. There is no curative therapy for the irreversible myocardial cell loss. This review will give an overview of the current options to restore the contractile force of the heart: the different stem cell sources as therapeutic agents in cardiac repair as well as more novel approaches like the activation of endogenous cell populations, the use of paracrine factors and engineered heart tissue.
Keywords: Cardiac regeneration, endogenous cell populations, paracrine factors, stem cell therapy, tissue engineering
Current Medicinal Chemistry
Title:Cardiac Regeneration: Stem Cells and Beyond
Volume: 19 Issue: 35
Author(s): A. T. Moerkamp and Marie-Jose Goumans
Affiliation:
Keywords: Cardiac regeneration, endogenous cell populations, paracrine factors, stem cell therapy, tissue engineering
Abstract: After myocardial infarction, the lost healthy myocardium is replaced by non-contractile scar tissue which may lead to the development of heart failure and death. There is no curative therapy for the irreversible myocardial cell loss. This review will give an overview of the current options to restore the contractile force of the heart: the different stem cell sources as therapeutic agents in cardiac repair as well as more novel approaches like the activation of endogenous cell populations, the use of paracrine factors and engineered heart tissue.
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Cite this article as:
T. Moerkamp A. and Goumans Marie-Jose, Cardiac Regeneration: Stem Cells and Beyond, Current Medicinal Chemistry 2012; 19 (35) . https://dx.doi.org/10.2174/0929867311209065993
DOI https://dx.doi.org/10.2174/0929867311209065993 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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