Abstract
The calcium ion is quite possibly the single most pervasive signaling molecule used by living organisms for the purpose of communicating internal and external states. It differs from other messengers in that it is neither created nor destroyed, but just moved around inside and outside the cell via transporters, pumps and channels to alter its concentration in specific cellular locations. These changes in free [Ca2+] are then detected by a wide array of Ca2+-binding effector proteins whose affinities are appropriately tuned to respond to a particular type of [Ca2+] change. This deceptively simple paradigm dominates the function of many cell types, for example in driving contraction of muscle, action potential generation in nerves, fluid, hormone, and enzyme secretion in secretory cells, and certain immune responses. However, the Ca2+ signal does not work in strict isolation, but rather is fine-tuned by many other signals, not the least of which is the other major second messenger, cyclic AMP (cAMP). Conversely, the cAMP pathway is subject to modification by the calcium signal and its various effectors at many different levels. These two fundamental second messengers, used throughout eukaryotes and even prokaryotes, are thus inextricably intertwined. The purpose of the present article is to provide an update on some of the recently described forms of reciprocal regulation between Ca2+ and cAMP signaling circuits, with emphasis on interactions that take place in localized domains of the cell.
Keywords: Fluorescence Resonance Energy Transfer (FRET), calcium/cAMP crosstalk, cAMP microdomains, adenylyl cyclase, protein kinase A (PKA), cAMP oscillations, STIM1
Current Medicinal Chemistry
Title:Interactions Between Calcium and cAMP Signaling
Volume: 19 Issue: 34
Author(s): A. M. Hofer
Affiliation:
Keywords: Fluorescence Resonance Energy Transfer (FRET), calcium/cAMP crosstalk, cAMP microdomains, adenylyl cyclase, protein kinase A (PKA), cAMP oscillations, STIM1
Abstract: The calcium ion is quite possibly the single most pervasive signaling molecule used by living organisms for the purpose of communicating internal and external states. It differs from other messengers in that it is neither created nor destroyed, but just moved around inside and outside the cell via transporters, pumps and channels to alter its concentration in specific cellular locations. These changes in free [Ca2+] are then detected by a wide array of Ca2+-binding effector proteins whose affinities are appropriately tuned to respond to a particular type of [Ca2+] change. This deceptively simple paradigm dominates the function of many cell types, for example in driving contraction of muscle, action potential generation in nerves, fluid, hormone, and enzyme secretion in secretory cells, and certain immune responses. However, the Ca2+ signal does not work in strict isolation, but rather is fine-tuned by many other signals, not the least of which is the other major second messenger, cyclic AMP (cAMP). Conversely, the cAMP pathway is subject to modification by the calcium signal and its various effectors at many different levels. These two fundamental second messengers, used throughout eukaryotes and even prokaryotes, are thus inextricably intertwined. The purpose of the present article is to provide an update on some of the recently described forms of reciprocal regulation between Ca2+ and cAMP signaling circuits, with emphasis on interactions that take place in localized domains of the cell.
Export Options
About this article
Cite this article as:
M. Hofer A., Interactions Between Calcium and cAMP Signaling, Current Medicinal Chemistry 2012; 19 (34) . https://dx.doi.org/10.2174/092986712804143286
DOI https://dx.doi.org/10.2174/092986712804143286 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Position of Endoscopic Procedures in the Treatment of Obesity
Current Clinical Pharmacology Melanocortin - 4 Receptor Agonists for the Treatment of Obesity
Current Topics in Medicinal Chemistry VIP and Drug Design
Current Pharmaceutical Design Culture Supernatants from Lactobacillus plantarum Induce Necrosis on a Human Promyelocytic Leukemia Cell Line
Endocrine, Metabolic & Immune Disorders - Drug Targets Machine Learning and Molecular Dynamics Based Insights into Mode of Actions of Insulin Degrading Enzyme Modulators
Combinatorial Chemistry & High Throughput Screening Regulation of Angiotensin II Receptor Expression
Current Pharmaceutical Design Epidemiology and Risk Factors of Cerebral Ischemia and Ischemic Heart Diseases: Similarities and Differences
Current Cardiology Reviews Can Diet and Physical Activity Limit Alzheimer's Disease Risk?
Current Alzheimer Research Transferrin and the Transferrin Receptor: Of Magic Bullets and Other Concerns
Inflammation & Allergy - Drug Targets (Discontinued) ESVS Guidelines: Section B - Diagnosis and Investigation of Patients with Carotid Stenosis
Current Vascular Pharmacology Subject Index To Volume 9
Current Medicinal Chemistry Investigating the Associations between Mediterranean Diet, Physical Activity and Living Environment with Childhood Asthma using Path Analysis
Endocrine, Metabolic & Immune Disorders - Drug Targets Pharmacogenetic Modulation of Platelet Inhibition
Current Pharmacogenomics and Personalized Medicine Cholesterol, Lipids, Amyloid Beta, and Alzheimers
Current Alzheimer Research Dipeptidyl Peptidase IV Inhibitors: The Next Generation of New Promising Therapies for the Management of Type 2 Diabetes
Current Topics in Medicinal Chemistry Analysis of Glycosylation and Other Post-Translational Modifications by Mass Spectrometry
Current Analytical Chemistry Anti-Aging Drugs – Prospect of Longer Life?
Current Medicinal Chemistry Effect of Non-Ionizing Electromagnetic Fields of Anthropic Origin on Male Fertility
Current Chemical Biology Pharmacological Potential of Exercise and RAS Vasoactive Peptides for Prevention of Diseases
Current Protein & Peptide Science The Art of Data Mining the Minefields of Toxicity Databases to Link Chemistry to Biology
Current Computer-Aided Drug Design