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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

One-Pot Approach to 4-Vinyl-1,2,3-Triazoles by Cycloaddition of Azides with Propargyl Alcohols Catalyzed by Cu(I)/Ru(III)/TFA

Author(s): Ji Su and Ruimao Hua

Volume 9 , Issue 6 , 2012

Page: [898 - 902] Pages: 5

DOI: 10.2174/157017912803901646

Price: $65

Abstract

An efficient and regioselective one-pot direct synthesis of 4-vinyl-1,2,3-triazoles via cycloaddition of azides with propargyl alcohols and dehydration catalyzed by a CuCl/RuCl3·3H2O bimetallic catalysts in the presence of TFA (Trifluoroacetic acid) is developed.

Keywords: Azides, Cuprous chloride, Propargyl alcohols, Ruthenium trichloride hydrate, 4-Vinyl-1, 2, 3-triazoles, Trifluoroacetic acid.


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