Abstract
The effect of extraction solvents (methanol, 95%ethanol, and water) on total phenolic contents and free radical scavenging activity (FRSA) of Gynura procumbens leaf was investigated. The contents of total phenolic and in vitro FRSA were significantly higher in the methanol extract compared to the 95% ethanol and water extracts. Consequently, the effect of the methanol extract on plasma lipid peroxidation and plasma total antioxidant status in carbon tetrachloride (CCl4) -induced oxidative stress in rats was determined. The administration of CCl4 to rats showed significant increase in plasma thiobarbituric acid reactive substances (TBARS) levels. The plasma lipid peroxidation elevation produced by CCl4 was reversed in rats fed with the methanol extract of G. procumbens leaf for 14 days before CCl4 challenge. Administration of CCl4 to rats did not showed significant alteration in plasma total antioxidant status (TAS).
Keywords: Antioxidant, extraction solvents, Gynura procumbens, lipid peroxidation, plasma, plant, substances, antioxidant, lipid, leaf.
Call for Papers in Thematic Issues
Ayurvedic medicinal therapeutic approaches for inflammatory and neurodegenerative disorders
Usually, in our elderly population, neurodegenerative disorders occur due to neuron death. Alzheimer?s disease (AD) is an irreversible and progressive neurodegenerative disease. Dementia is the leading cause of AD, which affects about 30 million people worldwide. According to the World Alzheimer report 2018, a new case of dementia develops every ...read more
Recent Advances in Biotransformation of Bioactive Terpenoids using Aspergillus niger
Biotransformation is the reaction catalyzed by biological catalysts of either isolated enzymes or whole cell cultures of microorganisms. This process has been extensively applied in the conversion of bioactive terpenoids with high regio- and stereospecifity. This process has been also applied in the lead discovery and development. Aspergillus niger has ...read more
Related Journals
Anti-Cancer Agents in Medicinal Chemistry
Current Analytical Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Combinatorial Chemistry & High Throughput Screening
Current Organic Chemistry
Current Medicinal Chemistry
Current Organic Synthesis
Central Nervous System Agents in Medicinal Chemistry
Mini-Reviews in Organic Chemistry
Related Books
Botanicals and Natural Bioactives: Prevention and Treatment of Diseases
Biosurfactants: A Boon to Healthcare, Agriculture & Environmental Sustainability
Frontiers in Computational Chemistry
Advances in Dye Degradation
Biological and Medical Significance of Chemical Elements
Frontiers In Medicinal Chemistry
Advances in Organic Synthesis
Frontiers in Natural Product Chemistry
Recent Advances in Analytical Techniques
Advanced Catalysts Based on Metal-organic Frameworks (Part 2)
18