Generic placeholder image

Current Genomics


ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Toll-Like Receptors and Human Disease: Lessons from Single Nucleotide Polymorphisms

Author(s): Yi-Tzu Lin, Amanda Verma and Conrad P. Hodgkinson

Volume 13, Issue 8, 2012

Page: [633 - 645] Pages: 13

DOI: 10.2174/138920212803759712

Price: $65


Toll-like receptors (TLRs), a large group of proteins which recognize various pathogen-associated molecular patterns, are critical for the normal function of the innate immune system. Following their discovery many single nucleotide polymorphisms within TLRs and components of their signaling machinery have been discovered and subsequently implicated in a wide range of human diseases including atherosclerosis, sepsis, asthma, and immunodeficiency. This review discusses the effect of genetic variation on TLR function and how they may precipitate disease.

Keywords: Atherosclerosis, Genetic association studies, Inflammation, Innate immunity, Single nucleotide polymorphisms, Toll-like receptors, sepsis, immunodeficiency, polymorphisms, Caenorhadbitis elegans.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy