Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion complexes with small molecules and portions of large compounds. These biocompatible, cyclic oligosaccharides do not elicit immune responses and have low toxicities in animals and humans. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current cyclodextrin-based therapeutics are described and possible future applications discussed with particular focus on oral drug administration. This article focuses on development of in vitro reliable and simple prototypes for oral drug delivery by combing chemical, structural and pharmacological knowledge available to date in order to create an optimal oral drug delivery system based on modified cyclodextrins. Practical in vitro model is also demonstrated.
Keywords: Cyclodextrin, drug delivery systems, host-guest chemistry, in vitro models, hydrophilic drugs, carbamazepine/β-cyclodextrin, chromatographic separations, HP-β-cyclodextrin, SBE-β-cyclodextrin, β-cyclodextrin.