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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

A Highly Efficient Green Synthesis of N-Alkyl 2-[(2-Oxo-2-Aryl Ethyl) Amino] Benzamide Derivatives from Reaction of Isatoic Anhydride, Primary Amines and 2-Bromoacethophenone

Author(s): Maryam Sabbaghan and Zinatossadat Hossaini

Volume 15, Issue 9, 2012

Page: [745 - 748] Pages: 4

DOI: 10.2174/138620712803519716

Price: $65

Abstract

N-alkyl 2-[(2-oxo-2-aryl ethyl)amino] benzamide derivatives have been synthesized in high yields. This involves three-component reaction of isatoic anhydride, primary amines in the presence of 2-bromoacethophenone derivatives. The reaction workup is simple and the products can be easily separated from the reaction mixture.

Keywords: 2-bromoacethophenone, Benzamide, green synthesis, one-pot synthesis, solvent-free, Isatoic Anhydride, Primary Amines, Diversity-oriented synthesis (DOS), heterocycles compound, pharmacological properties


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