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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

An Efficient Four-Component, One-Pot Synthesis of 6-Amino-4-Aryl-3- Methyl-2,4-Dihydropyrano[2,3-C]Pyrazole-5-Carbonitriles Under Phase- Transfer Catalyst

Author(s): Keyume Ablajan, Wang Liju, Anagu Tuoheti and Yakefujiang Kelimu

Volume 9, Issue 9, 2012

Page: [639 - 643] Pages: 5

DOI: 10.2174/157017812803521135

Price: $65


A series of 6-amino-4-aryl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitriles (5a–5j) were synthesized by four-component one-pot reaction of methyl acetoacetate (or ethyl acetoacetate), hydrazine hydrate, arylaldehydes and malononitrile in the presence of phase transfer catalyst. A highest yield of product was obtained while using 30 mol % of HDBAC as a catalyst.

Keywords: Four-component reaction, one-pot synthesis, phase-transfer catalysis, pyrano[2, 3-c]pyrazole, phase-transfer catalysis, Multi component reaction (MCR), bioactive, pharmacological, Green method, catalyst, CN moiety

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