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Letters in Organic Chemistry


ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Synthesis and Application of Novel Dithiane Alcohol Ligand Based on Chiral Cyclopropane-backbone for Asymmetric Ethylation of Aromatic Aldehydes

Author(s): Risong Na, Bo Wang, Honglei Liu, Qinghua Bian, Jiangchun Zhong, Min Wang and Hongchao Guo

Volume 9, Issue 9, 2012

Page: [622 - 627] Pages: 6

DOI: 10.2174/157017812803521171

Price: $65


A novel chiral dithiane alcohol ligand, based on chiral cyclopropane-backbone, was easily prepared from (–)- 1R-cis-caronaldehyde. The chiral ligand was used in asymmetric ethylation of aromatic aldehydes to afford the corresponding secondary alcohols with moderate to good enantioselectivity.

Keywords: Asymmetric, cyclopropane-backbone, chiral ligand, diethylzinc addition, dithiane alcohol, catalysis, structurally diverse, enantioselectivities, potential, Bruker Tensor 27 spectrometer

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