Abstract
Molecular profiling of cancers can potentially yield novel gene markers of therapeutic prediction, which would aid our ability to tailor targeted therapy regimens specific to each patient. Public data from gene expression profiling may yield clues as to what oncogenic signaling pathways are deregulated in cancers, and what drugs may effectively counteract the aberrant gene regulation patterns observed. Data are also available on panels of cancer cell lines, which have been both profiled at the gene expression level and extensively characterized for drug responses, allowing us to identify geneto- drug correlations. Profiling tumors from patients undergoing adjuvant or neoadjuvant drug treatment can also yield markers of therapeutic response. In this review, we will examine recent studies aimed at our eventually being able to use the molecular profile of a tumor to predict drug response. The profiling data from these studies is publicly available, and can be re-examined by researchers with different questions in mind, offering us a large number of biomarker candidates that could potentially be tested in the clinical setting.
Keywords: Gene expression profiling, oncogenic signatures, drug response prediction, molecular profile of a tumor, gene regulation, CONNECTIVITY MAP, oncogenic signaling pathways, ER+) breast tumors, biomarkers, gene transcription.
Current Drug Targets
Title:Molecular Classification and Drug Response Prediction in Cancer
Volume: 13 Issue: 12
Author(s): Chad J. Creighton
Affiliation:
Keywords: Gene expression profiling, oncogenic signatures, drug response prediction, molecular profile of a tumor, gene regulation, CONNECTIVITY MAP, oncogenic signaling pathways, ER+) breast tumors, biomarkers, gene transcription.
Abstract: Molecular profiling of cancers can potentially yield novel gene markers of therapeutic prediction, which would aid our ability to tailor targeted therapy regimens specific to each patient. Public data from gene expression profiling may yield clues as to what oncogenic signaling pathways are deregulated in cancers, and what drugs may effectively counteract the aberrant gene regulation patterns observed. Data are also available on panels of cancer cell lines, which have been both profiled at the gene expression level and extensively characterized for drug responses, allowing us to identify geneto- drug correlations. Profiling tumors from patients undergoing adjuvant or neoadjuvant drug treatment can also yield markers of therapeutic response. In this review, we will examine recent studies aimed at our eventually being able to use the molecular profile of a tumor to predict drug response. The profiling data from these studies is publicly available, and can be re-examined by researchers with different questions in mind, offering us a large number of biomarker candidates that could potentially be tested in the clinical setting.
Export Options
About this article
Cite this article as:
J. Creighton Chad, Molecular Classification and Drug Response Prediction in Cancer, Current Drug Targets 2012; 13 (12) . https://dx.doi.org/10.2174/138945012803530143
DOI https://dx.doi.org/10.2174/138945012803530143 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Central Nervous System Agents Used as Trypanosoma cruzi Infection Chemotherapy: Phenothiazines and Related Compounds
Current Medicinal Chemistry - Anti-Infective Agents Astrocytes: Adhesion Molecules and Immunomodulation
Current Drug Targets Cross Talk between the Cardiovascular and Nervous Systems:Neurotrophic Effects of Vascular Endothelial Growth Factor (VEGF) and Angiogenic Effects of Nerve Growth Factor (NGF)-Implications in Drug Development
Current Pharmaceutical Design Target Genetic Abnormalities for the Treatment of Colon Cancer and Its Progression to Metastasis
Current Drug Targets Neuropeptide FF Inhibits LPS-Mediated Osteoclast Differentiation of RAW264.7 Cells
Protein & Peptide Letters Peptides for Tumour Therapy and Diagnosis: Current Status and Future Directions
Current Medicinal Chemistry Novel Metals and Metal Complexes as Platforms for Cancer Therapy
Current Pharmaceutical Design Gynecomastia in Infants, Children, and Adolescents
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Prolyl Oligopeptidase: A Rising Star on the Stage of Neuroinflammation Research
CNS & Neurological Disorders - Drug Targets Cell Cycle and Cancer: The G1 Restriction Point and the G1 / S Transition
Current Genomics Physiology and Pathophysiology of Na+/H+ Exchange Isoform 1 in the Central Nervous System
Current Neurovascular Research Superparamagnetic Magnetite (Fe3O4) Nanoparticles for Bio-Applications
Recent Patents on Materials Science [177Lu]-DOTA0-Tyr3-Octreotate: A Potential Targeted Radiotherapeutic for the Treatment of Medulloblastoma
Current Radiopharmaceuticals Mitochondrially-Targeted Therapeutic Strategies for Alzheimer’s Disease
Current Alzheimer Research Hedgehog Signaling and Urological Cancers
Current Drug Targets Regulation and Function of DNA and Histone Methylations
Current Pharmaceutical Design Copper Complexes as Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review
Anti-Cancer Agents in Medicinal Chemistry Safety of Nanoparticles in Medicine
Current Drug Targets Chromatin Structure and Epigenetics of Tumour Cells: A Review
Cardiovascular & Hematological Disorders-Drug Targets