Abstract
The blood-brain barrier (BBB), which impedes drug penetration into the central nervous system, is composed of specific structures formed by brain capillary endothelial cells and sheathed by astrocytic end-feet through basement membrane. Many brain drug delivery strategies have focused on adsorptive-mediated transcytosis (AMT), which is triggered by electrostatic interaction between cationic molecules and anionic microdomains on the cytoplasm membrane of the brain capillary endothelial cells. AMT-based drug delivery to the brain can be achieved by using cationic proteins and basic oligopeptides such as cell-penetrating peptides as targetors. Large therapeutic molecules such as neuropeptides and proteins or even drug-encapsulated vectors such as liposomes and nanoparticles can be allowed to access brain parenchyma through AMT when conjugated with these cationic targetors. In this review, I briefly discuss adsorptive-mediated brain delivery systems that may provide physiologic-based strategies for enhanced delivery of therapeutic substances through the BBB.
Keywords: Adsorptive-mediated transcytosis (AMT), blood-brain barrier (BBB), cationized protein, nanoparticle, toxicity, central nervous system, endothelial cells, adsorptive-mediated transcytosis (AMT), cationic proteins, neuropeptides, brain capillary endothelial cells (BCECs), astrocytic end-feet, Large therapeutic molecules, blood milieu
Current Pharmaceutical Biotechnology
Title:Adsorptive-Mediated Brain Delivery Systems
Volume: 13 Issue: 12
Author(s): Wei Lu
Affiliation:
Keywords: Adsorptive-mediated transcytosis (AMT), blood-brain barrier (BBB), cationized protein, nanoparticle, toxicity, central nervous system, endothelial cells, adsorptive-mediated transcytosis (AMT), cationic proteins, neuropeptides, brain capillary endothelial cells (BCECs), astrocytic end-feet, Large therapeutic molecules, blood milieu
Abstract: The blood-brain barrier (BBB), which impedes drug penetration into the central nervous system, is composed of specific structures formed by brain capillary endothelial cells and sheathed by astrocytic end-feet through basement membrane. Many brain drug delivery strategies have focused on adsorptive-mediated transcytosis (AMT), which is triggered by electrostatic interaction between cationic molecules and anionic microdomains on the cytoplasm membrane of the brain capillary endothelial cells. AMT-based drug delivery to the brain can be achieved by using cationic proteins and basic oligopeptides such as cell-penetrating peptides as targetors. Large therapeutic molecules such as neuropeptides and proteins or even drug-encapsulated vectors such as liposomes and nanoparticles can be allowed to access brain parenchyma through AMT when conjugated with these cationic targetors. In this review, I briefly discuss adsorptive-mediated brain delivery systems that may provide physiologic-based strategies for enhanced delivery of therapeutic substances through the BBB.
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Cite this article as:
Lu Wei, Adsorptive-Mediated Brain Delivery Systems, Current Pharmaceutical Biotechnology 2012; 13 (12) . https://dx.doi.org/10.2174/138920112803341851
DOI https://dx.doi.org/10.2174/138920112803341851 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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