Abstract
Many approaches have been applied in biological and clinical studies aimed at simultaneously monitoring the expression of a large number of genes and at identifying the gene expression patterns associated with specific cell types. In the last decade, microarrays are emerged as an innovative tool to detect differentially expressed genes as disease-specific markers and to cluster the co-expressed genes regulating the molecular interactions. In fact, microarrays have been widely used for tumour diagnosis and classification, prediction of prognoses and treatment, pharmaceutical safety assessment, and understanding of molecular mechanisms, biochemical pathways, and gene networks. Besides the clinical relevance and the wide application of this technology, several problems remain to be addressed. This review illustrates the current and future directions of the microarray platform, and highlights the successes and strengths, as well as the shortcomings and limitations of this technology. An overview of microarray impact on the ocular and craniofacial diseases is provided.
Keywords: Craniofacial diseases, Gene expression, Microarray analysis, Ocular diseases
Current Pharmaceutical Analysis
Title: Microarrays as a Tool for Gene Expression Profiling: Application in Ocular and Craniofacial Research
Volume: 3 Issue: 3
Author(s): Maria Visalli, Mario Venza, Isabella Venza, Claudia Torino and Diana Teti
Affiliation:
Keywords: Craniofacial diseases, Gene expression, Microarray analysis, Ocular diseases
Abstract: Many approaches have been applied in biological and clinical studies aimed at simultaneously monitoring the expression of a large number of genes and at identifying the gene expression patterns associated with specific cell types. In the last decade, microarrays are emerged as an innovative tool to detect differentially expressed genes as disease-specific markers and to cluster the co-expressed genes regulating the molecular interactions. In fact, microarrays have been widely used for tumour diagnosis and classification, prediction of prognoses and treatment, pharmaceutical safety assessment, and understanding of molecular mechanisms, biochemical pathways, and gene networks. Besides the clinical relevance and the wide application of this technology, several problems remain to be addressed. This review illustrates the current and future directions of the microarray platform, and highlights the successes and strengths, as well as the shortcomings and limitations of this technology. An overview of microarray impact on the ocular and craniofacial diseases is provided.
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Cite this article as:
Maria Visalli , Mario Venza , Isabella Venza , Claudia Torino and Diana Teti , Microarrays as a Tool for Gene Expression Profiling: Application in Ocular and Craniofacial Research, Current Pharmaceutical Analysis 2007; 3 (3) . https://dx.doi.org/10.2174/157341207781369312
DOI https://dx.doi.org/10.2174/157341207781369312 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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