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Current Molecular Medicine


ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

Gene Profiles within the Adult Subventricular Zone Niche:Proliferation, Differentiation and Migration of Neural Progenitor Cells in the Ischemic Brain

Author(s): Rui Lan Zhang, Zheng Gang Zhang and Michael Chopp

Volume 7, Issue 5, 2007

Page: [459 - 462] Pages: 4

DOI: 10.2174/156652407781387136

Price: $65


Focal cerebral ischemia induces neurogenesis in the subventricular zone (SVZ) of the adult human brain. Neurogenesis is controlled by proliferation, differentiation, and migration of neural progenitor cells. This article reviews emerging data that changes of cell cycle kinetics of neural progenitor cells induced by stroke contribute to increased neural progenitor cell proliferation and that gene profiles control proliferation, differentiation, and migration of neural progenitor cells within the SVZ niche. A better understanding of gene profiles that control the biological function of adult SVZ neural progenitor cells could lead to more selective and effective treatments to enhance neurogenesis during stroke recovery.

Keywords: Cerebral ischemia, neurogenesis, gene profiles

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