Abstract
Mitochondria are essential for various biological processes including cellular energy production. The oxidative stress theory of aging proposes that mitochondria play key roles in aging by generating reactive oxygen species (ROS), which indiscriminately damage macromolecules and lead to an age-dependent decline in biological function. However, recent studies show that increased levels of ROS or inhibition of mitochondrial function can actually delay aging and increase lifespan. The aim of this review is to summarize recent findings regarding the role of mitochondria in organismal aging processes. We will discuss how mitochondria contribute to evolutionarily conserved longevity pathways, including mild inhibition of respiration, dietary restriction, and target of rapamycin (TOR) signaling.
Keywords: Mitochondria, Aging, Reactive oxygen species, Dietary restriction, Target of rapamycin (TOR)
Current Genomics
Title:Mitochondria and Organismal Longevity
Volume: 13 Issue: 7
Author(s): Ara B. Hwang, Dae-Eun Jeong and Seung-Jae Lee
Affiliation:
Keywords: Mitochondria, Aging, Reactive oxygen species, Dietary restriction, Target of rapamycin (TOR)
Abstract: Mitochondria are essential for various biological processes including cellular energy production. The oxidative stress theory of aging proposes that mitochondria play key roles in aging by generating reactive oxygen species (ROS), which indiscriminately damage macromolecules and lead to an age-dependent decline in biological function. However, recent studies show that increased levels of ROS or inhibition of mitochondrial function can actually delay aging and increase lifespan. The aim of this review is to summarize recent findings regarding the role of mitochondria in organismal aging processes. We will discuss how mitochondria contribute to evolutionarily conserved longevity pathways, including mild inhibition of respiration, dietary restriction, and target of rapamycin (TOR) signaling.
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Cite this article as:
B. Hwang Ara, Jeong Dae-Eun and Lee Seung-Jae, Mitochondria and Organismal Longevity, Current Genomics 2012; 13 (7) . https://dx.doi.org/10.2174/138920212803251427
DOI https://dx.doi.org/10.2174/138920212803251427 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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