Abstract
Progress in aging research has identified genetic and environmental factors that regulate longevity across species. The nematode worm Caenorhabditis elegans is a genetically tractable model system that has been widely used to investigate the molecular mechanisms of aging, and the development of RNA interference (RNAi) technology has provided a powerful tool for performing large-scale genetic screens in this organism. Genome-wide screens have identified hundreds of genes that influence lifespan, many of which fall into distinct functional classes and pathways. The purpose of this review is to summarize the results of large-scale RNAi longevity screens in C. elegans, and to provide an in-depth comparison and analysis of their methodology and most significant findings.
Keywords: Dietary restriction, FOXO, Genomic, Longevity, IGF-1, Insulin, Mitochondria
Current Genomics
Title:Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans
Volume: 13 Issue: 7
Author(s): Melana E. Yanos, Christopher F. Bennett and Matt Kaeberlein
Affiliation:
Keywords: Dietary restriction, FOXO, Genomic, Longevity, IGF-1, Insulin, Mitochondria
Abstract: Progress in aging research has identified genetic and environmental factors that regulate longevity across species. The nematode worm Caenorhabditis elegans is a genetically tractable model system that has been widely used to investigate the molecular mechanisms of aging, and the development of RNA interference (RNAi) technology has provided a powerful tool for performing large-scale genetic screens in this organism. Genome-wide screens have identified hundreds of genes that influence lifespan, many of which fall into distinct functional classes and pathways. The purpose of this review is to summarize the results of large-scale RNAi longevity screens in C. elegans, and to provide an in-depth comparison and analysis of their methodology and most significant findings.
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Cite this article as:
E. Yanos Melana, F. Bennett Christopher and Kaeberlein Matt, Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans, Current Genomics 2012; 13 (7) . https://dx.doi.org/10.2174/138920212803251391
DOI https://dx.doi.org/10.2174/138920212803251391 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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