Generic placeholder image

Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Selective Inhibition of Inducible Nitric Oxide Synthase by Derivatives of Acetamidine

Author(s): Cristina Maccallini, Antonia Patruno, Alessandra Ammazzalorso, Barbara De Filippis, Marialuigia Fantacuzzi, Sara Franceschelli, Letizia Giampietro, Simona Masella, Maria Luisa Tricca and Rosa Amoroso

Volume 8, Issue 6, 2012

Page: [991 - 995] Pages: 5

DOI: 10.2174/1573406411208060991

Price: $65

Abstract

A new series of phenyl- and heteryl acetamidines were synthesized and evaluated as inhibitors of nitric oxide synthases (NOS). While the N-substitution of the acetamidine moiety with different heterocycles appears to completely destroy the activity, linking the phenyl core preserves it. Moreover, it was observed a strong dependence of the phenylacetamidines potency of action from the length of the alkyl chain that connects the aromatic ring to the acetamidine moiety.

Keywords: Nitric oxide, Nitric oxide synthase, Selective inducible NOS inhibitors, Acetamidines, heterocycles, inorganic, neurodegenerative diseases, cytokines, polysaccharides, amino acid

« Previous

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy