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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Brain Connectivity Studies in Schizophrenia: Unravelling the Effects of Antipsychotics

Author(s): Ayna B. Nejad, Bjorn H. Ebdrup, Birte Y. Glenthoj and Hartwig R. Siebner

Volume 10, Issue 3, 2012

Page: [219 - 230] Pages: 12

DOI: 10.2174/157015912803217305

Price: $65


Impaired brain connectivity is a hallmark of schizophrenia brain dysfunction. However, the effect of drug treatment and challenges on the dysconnectivity of functional networks in schizophrenia is an understudied area. In this review, we provide an overview of functional magnetic resonance imaging studies examining dysconnectivity in schizophrenia and discuss the few studies which have also attempted to probe connectivity changes with antipsychotic drug treatment. We conclude with a discussion of possible avenues for further investigation.

Keywords: Antipsychotic drug treatment, brain connectivity, fMRI, schizophrenia

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