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Current Drug Metabolism


ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Dendrimers in Cancer Therapeutics and Diagnosis

Author(s): Rui Guo and Xiangyang Shi

Volume 13, Issue 8, 2012

Page: [1097 - 1109] Pages: 13

DOI: 10.2174/138920012802850010

Price: $65


Dendrimers represent a class of monodispersed synthetic macromolecules with a well defined three-dimensional structure of nanometer dimension in which a series of layered branches regularly extend from a central core molecule. Due to their precise nanoscale sizes, well-defined branched structures, and various surface modifications, dendrimers have been extensively investigated in a wide range of applications in the biomedical field, particularly in the therapeutics and diagnosis of cancer. This article gives an overview of the recent advances of dendrimers and dendrimer-based hybrid nanoparticles for cancer therapeutics and diagnosis applications.

Keywords: Dendrimer, anticancer drug delivery, cancer diagnosis, nanometer, Hybrid, Nanomedicine, gene regulation, dendritic branches, linear polymers, bioassemblies

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