Abstract
Dendrimers represent a class of monodispersed synthetic macromolecules with a well defined three-dimensional structure of nanometer dimension in which a series of layered branches regularly extend from a central core molecule. Due to their precise nanoscale sizes, well-defined branched structures, and various surface modifications, dendrimers have been extensively investigated in a wide range of applications in the biomedical field, particularly in the therapeutics and diagnosis of cancer. This article gives an overview of the recent advances of dendrimers and dendrimer-based hybrid nanoparticles for cancer therapeutics and diagnosis applications.
Keywords: Dendrimer, anticancer drug delivery, cancer diagnosis, nanometer, Hybrid, Nanomedicine, gene regulation, dendritic branches, linear polymers, bioassemblies
Current Drug Metabolism
Title:Dendrimers in Cancer Therapeutics and Diagnosis
Volume: 13 Issue: 8
Author(s): Rui Guo and Xiangyang Shi
Affiliation:
Keywords: Dendrimer, anticancer drug delivery, cancer diagnosis, nanometer, Hybrid, Nanomedicine, gene regulation, dendritic branches, linear polymers, bioassemblies
Abstract: Dendrimers represent a class of monodispersed synthetic macromolecules with a well defined three-dimensional structure of nanometer dimension in which a series of layered branches regularly extend from a central core molecule. Due to their precise nanoscale sizes, well-defined branched structures, and various surface modifications, dendrimers have been extensively investigated in a wide range of applications in the biomedical field, particularly in the therapeutics and diagnosis of cancer. This article gives an overview of the recent advances of dendrimers and dendrimer-based hybrid nanoparticles for cancer therapeutics and diagnosis applications.
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Cite this article as:
Guo Rui and Shi Xiangyang, Dendrimers in Cancer Therapeutics and Diagnosis, Current Drug Metabolism 2012; 13 (8) . https://dx.doi.org/10.2174/138920012802850010
DOI https://dx.doi.org/10.2174/138920012802850010 |
Print ISSN 1389-2002 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5453 |
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