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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Dithiocarbamate complexes as radiopharmaceuticals for medical imaging

Author(s): David J. Berry, Rafael Torres Martin de Rosales, Putthiporn Charoenphun and Philip J. Blower

Volume 12, Issue 12, 2012

Page: [1174 - 1183] Pages: 10

DOI: 10.2174/138955712802762112

Price: $65

Abstract

Over the past 30 years dithiocarbamate ligands have found application in radiopharmaceutical metal-ligand complexes to image a range of disease states. The vast majority of research and applications, and the widest range of complex structures, have involved radionuclides of technetium and rhenium. Considering the extent of coordination chemistry of dithiocarbamate ligands described elsewhere in this issue, the extent of radiopharmaceutical application with metallic radionuclides is surprisingly narrow. Here we summarise the types of radiopharmaceutical complexes studied and the uses, and potential uses, to which they have been put in nuclear medicine.

Keywords: Copper, dithiocarbamate, nuclear medicine, radiopharmaceuticals, rhenium, technetium.


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