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Mini-Reviews in Medicinal Chemistry


ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Sex Steroid Hormone Effects in Normal and Pathologic Conditions in Lung Physiology

Author(s): A. Gonzalez-Arenas and J. Agramonte-Hevia

Volume 12, Issue 11, 2012

Page: [1055 - 1062] Pages: 8

DOI: 10.2174/138955712802762194

Price: $65


Progesterone and estradiol participate in the regulation of many pulmonary functions, for example progesterone mediates the fall of alveolar carbon dioxide tension observed in the luteal phase of the menstrual cycle and during pregnancy in humans, when progesterone levels are high. The treatment with estradiol diminishes vasoconstriction and hypoxia. Progesterone and estradiol in addition to participating in non-pathological functions such as vasodilation and lung maturation, also have influence on pathologies as asthma, cystic diseases and cancer. Therefore this review will provide an overview of the action and effects of these hormones in lung, their mechanism of action through their intracellular receptors and their influence over asthma, cystic lung diseases and cancer.

Keywords: Estradiol, estrogen receptor, lung, progesterone, progesterone receptor, ER-α, protein–antibody, colony-stimulating factor, edema

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