Resuscitation-promoting Factors (Rpf): In Search of Inhibitors

Title:Resuscitation-promoting Factors (Rpf): In Search of Inhibitors

Volume: 19 Issue: 10

Author(s): Arseny S. Kaprelyants, Galina V. Mukamolova, Alessia Ruggiero, Vadim A. Makarov, Galina R. Demina, Margarita O. Shleeva, Vasilii D. Potapov and Pavel A. Shramko

Affiliation:

Keywords: Inhibitors, latency, nitrophenylthiocyanates, resuscitation, Rpf, tuberculosis, Mycobacterium tuberculosis, cell wall hydrolysing enzymes, therapeutic agents, molecular mechanisms

Abstract: Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity.

Cite this article as:

S. Kaprelyants Arseny, V. Mukamolova Galina, Ruggiero Alessia, A. Makarov Vadim, R. Demina Galina, O. Shleeva Margarita, D. Potapov Vasilii and A. Shramko Pavel, Resuscitation-promoting Factors (Rpf): In Search of Inhibitors, Protein & Peptide Letters 2012; 19 (10) . https://dx.doi.org/10.2174/092986612802762723